Data

Year of publication

2020

Type

Quantitative

Design

Animal study

Classification

N/A

Country studied

N/A

Data

Primary

Data Collected

Other

Study setting

Laboratory

Age group of participant

Rats/6-67 days

Participant sex

Male

Target population

N/A

Sample size

n=52 (wistar rats)

Nicotinamide riboside reduces cardiometabolic risk factors and modulates cardiac oxidative stress in obese Wistar rats under caloric restriction./Life Sciences

Goal

Investigate the effects of nicotinamide riboside (NR), isolated or combined with caloric restriction (CR).

Results

In obese rats, treatment with NR alone mitigated final body weight gain, reduced adiposity (visceral and subcutaneous), improved insulin resistance, and decreased TG/HDL ratio and heart size. For rats under caloric restriction, treatment with NR increased antioxidant capacity via glutathione peroxidase and catalase enzymes and reduced the pro-oxidant complex NADPH oxidase. Hyperglycemia, hypertriglyceridemia and elevated levels of TBARS in the heart were state-dependent adverse effects, induced by treatment with NR.

Authors

Macedo de Castro J, Fagundes Assumpção JA, Stein DJ, Toledo RS, Silva LS, Caumo W, Carraro CC, Rosa Araujo AS, Torres I.

Journal

DOI