Year of publication
Age group of participant
n=52 (wistar rats)
Nicotinamide riboside reduces cardiometabolic risk factors and modulates cardiac oxidative stress in obese Wistar rats under caloric restriction
Investigate the effects of nicotinamide riboside (NR), isolated or combined with caloric restriction (CR).
In obese rats, treatment with NR alone mitigated final body weight gain, reduced adiposity (visceral and subcutaneous), improved insulin resistance, and decreased TG/HDL ratio and heart size. For rats under caloric restriction, treatment with NR increased antioxidant capacity via glutathione peroxidase and catalase enzymes and reduced the pro-oxidant complex NADPH oxidase. Hyperglycemia, hypertriglyceridemia and elevated levels of TBARS in the heart were state-dependent adverse effects, induced by treatment with NR.
Macedo de Castro J, Fagundes Assumpção JA, Stein DJ, Toledo RS, Silva LS, Caumo W, Carraro CC, Rosa Araujo AS, Torres I.