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Food additives containing nanoparticles induce gastrotoxicity, hepatotoxicity and alterations in animal behavior: The unknown role of oxidative stress
Analyze the evidence of gastrotoxicity, hepatotoxicity and the impact of microbiota on gut-brain and gut-liver axis induced by titanium dioxide (E171), iron oxides and hydroxides (E172), silver (E174), and gold (E175) are highly used as colorants while silicon dioxide (E551) and their non-food grade nanosized counterparts after oral consumption.
These food additives induce gastrotoxicity, hepatotoxicity and alterations in gut microbiota and most evidence points out oxidative stress as the main mechanism of toxicity, however, the role of oxidative stress as the main mechanism needs to be explored further.
Medina-Reyes EI, Rodríguex-Ibarra C, Déciga-Alcaraz A, Diaz-Urbina D, Chirino YI, Pedraza-Chaverri J.
Food and Chemical Toxicology