Data

Year of publication

2020

Type

Quantitative

Design

Longitudinal

Classification

NOVA

Country studied

Italy

Data

Primary

Data Collected

One ood frequency

Study setting

Household

Age group of participant

Adults/35 and older

Participant sex

Mixed

Target population

General

Sample size

n=22810 (participants)

Consumption of ultra-processed foods and beverages is associated with increased risk of cardiovascular mortality in the moli-sani study cohort. Circulation

Goal

Find association between UPFB consumption and mortality risk in a large sample of the Italian population and tested whether some known cardiovascular disease (CVD) risk factors and nutrients could be on the pathway of this relation.

Results

Over a median follow up of 8.3 y, 1,235 deaths were ascertained. As opposed to lower intake (<2 servings/d), individuals reporting high intake of UPFB (>4 servings/d) experienced an increased risk of CVD mortality (HR=1.50; 95%CI 1.18-1.92) and of death for ischemic heart (IHD)/cerebrovascular disease (1.56; 1.13-2.14). An upward trend was found for all-cause mortality too (1.15; 1.00-1.34). Biomarkers of renal function (cystatin C and creatinine) or of lipid metabolisms were likely to be on the pathway between UPFB and CVD mortality. Among selected macronutrients, high content of sugar and saturated fats possibly drove the relation of UPFB with CVD mortality. High intake of ‘healthy’ UPFB was associated with an increased trend of risk comparable to that associated with ‘unhealthy’ UPFB.

Authors

Bonaccio M, Di Castelnuovo AF, Costanzo S, Curtis A, Persichllo M, et al.

Journal

DOI