Year of publication
Other (cafeteria diet)
Age group of participant
Old rats/6-8 weeks
Cafeteria-diet induced obesity results in impaired cognitive functioning in a rodent model
Evaluate the effect of a chronic 20-week CAF feeding period on metabolic and cognitive functioning in a Sprague-Dawley rats.
CAF rats consistently showed higher food intakes and consumed six times the energy of chow-fed rats, being significantly heavier by week 5. CAF rats further exhibited greater abdominal widths, fat pads, and larger fatty livers, as well as compromised glucose tolerance. Hyperinsulinemia and dyslipidaemia with elevated serum cholesterol and triglyceride levels and reduced HDL cholesterol were also evident along with a pro-inflammatory profile in the CAF rats.Cognitive decline in CAF rats manifested as a decline in long-term retention memory in the MWM. Further, CAF rats exhibited deficits in recognition memory as they spent less time exploring the novel object than chow-fed rats in the NOR task.
Lewis AR, Singh S, Youssef Farid F.