Data

Year of publication

2019

Type

Quantitative

Design

Animal study

Classification

Other (cafeteria diet)

Country studied

N/A

Data

Primary

Data Collected

N/A

Study setting

Laboratory

Age group of participant

Old rats/6-8 weeks

Participant sex

Male

Target population

N/A

Sample size

n=18 (animals)

Cafeteria-diet induced obesity results in impaired cognitive functioning in a rodent model

Goal

Evaluate the effect of a chronic 20-week CAF feeding period on metabolic and cognitive functioning in a Sprague-Dawley rats.

Results

CAF rats consistently showed higher food intakes and consumed six times the energy of chow-fed rats, being significantly heavier by week 5. CAF rats further exhibited greater abdominal widths, fat pads, and larger fatty livers, as well as compromised glucose tolerance. Hyperinsulinemia and dyslipidaemia with elevated serum cholesterol and triglyceride levels and reduced HDL cholesterol were also evident along with a pro-inflammatory profile in the CAF rats.Cognitive decline in CAF rats manifested as a decline in long-term retention memory in the MWM. Further, CAF rats exhibited deficits in recognition memory as they spent less time exploring the novel object than chow-fed rats in the NOR task.

Authors

Lewis AR, Singh S, Youssef Farid F.

Journal

Heliyon

DOI