Year of publication
Other (cafeteria diet)
Age group of participant
Old rats/3 weeks
A physiological characterization of the Cafeteria diet model of metabolic syndrome in the rat
Assess the ability of the CAF diet to produce metabolic syndrome in Sprague-Dawley rats as well as the degree to which these features could be reversed through switching to a healthy diet. Examined the effects of the CAF diet on hippocampal spatial learning and memory using the Barnes maze as well as on neuroinflammation by quantifying microglial cell density.
These results demonstrate that the CAF diet is very effective in creating metabolic syndrome with hippocampal inflammation in rats over a relatively short time span. This model may be of great heuristic importance in determining potential reversibility of metabolic and cerebrovascular pathologies across the lifespan and as a co-morbid factor in other disease models such as stroke.
Gomez-Smith M, Karthikeyan S, Jeffers MS, et al.
Physiology & Behavior